Liquid Chromatography Mass Spectroscopy Triple Quadra pole LC-MS and MS

Liquid Chromatography Mass Spectroscopy Triple Quadra pole LC-MS and MS

Triple Quadruple LC/MS
Delivers superior sensitivity for trace level analysis with performance specifications in signal-to-noise (S/N) and instrument detection limit (IDL). IDL is a rigorous, statistically based metric that indicates practical sensitivity performance of your quantitative assays.
Achieves sensitivity and resolution specifications with auto tune.
The triple quadruple provides superior analytical sensitivity, renowned reliability, and overall system robustness. proven choices for quantitative applications in food testing, toxicology, and environmental analyses

Single point of control: Single-point data system method capability with full control of HPLC systems and Triple Quadruple LC/MS System
LC Part:  Double-piston with high flow constay and low pulsation, <0.1Mpa.
High pressure pump that can simultaneously pump four degassed solvents (A, B, C, D)
Used as quaternary low-pressure gradient
Optimal for narrow bore chromatography
Built-in system controller with four time-based programmable switches as well as other control signals
Display of pressure profile deviations maintenance logbook function
Gradient/concentration precision: ±0.5
Suitable for use in variable temperature: 10 – 30 oC
Flow rate change:0.001 – 5mL/min
Solvent channel:  4
Flow rate precision: 0.075% RSD
Voltage requirement:  220±10V, Frequency 50/60Hz
Auto sampler
Injection method - Needle-in-flow path
Injection volume accuracy - ±1%
Injection volume reproducibility - RSD: ± 0.2uL
100 or more Sample plate with position for dilution function
Oven/ Column compartment
length: Suitable to handle column length of 50 – 250mm
Temperature setting range: 15 – 100OC ± 10oC
Voltage requirement: 220±10V, Frequency 50/60Hz
Safety and maintenance:  Extensive diagnostics, Error detection and display leak detection,
Safe leak handling,
Leak output signal for shutdown of pumping system,
Low voltage in major maintenance areas
GLP features:  early maintenance feedback (EMF) for continuous tracking of instrument usage with user-settable limits (purge interval) and feedback messages electronic records of maintenance and errors, automated OQ/PV procedures
Software: Unmatched ease-of-use— the latest generation of software features that has intuitive dashboard layout with gadgets that guides through every step of the analysis.
The innovative Method Setup Wizard automatically builds methods based on a few simple questions about the application, or from the analysis of a typical sample.
Software which enables the use of remote monitor app to check and control the instrument wherever and whenever wanted.

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Enable quickly and simultaneously estimate the concentration of all targeted analyte in a sample
Flexible quality control checks – Automate the monitoring of everything from calibration to internal standard responses during a run, ensuring reliable data even during unattended operation.
Acquisition in full spectrum, peak hopping and time resolved modes, fully automated quantitation
Support semi-quantitative analysis with rapid screening of unknowns.  
Software platforms seamlessly integrate with environmental, food and beverage, clinical research, forensic toxicology and other applications, ensuring that the greatest possible information is extracted from every bit of data and user friendly
Should support semi-quantitative analysis with rapid screening of unknowns.
Data archival and retrieval functions.
Data Reporting Programming of customized analysis routines.
System diagnostics software
21 CFR part 11 compatibility
Offline data analysis
Triple Quad LC/MS part:  Time programming:
Polarity change in time segment
Scan and SIM or MRM (plus other modes of data collection)
Dynamic and triggered MRM aligns MRMs with compound retention time
Solvent divert through calibrant delivery system valve
Wide range of ionization sources
Electrospray (ESI)
Dual mode (Atmospheric Pressure Photo Ionization)/APCI source (Atmospheric Pressure Chemical Ionization) source.
Multi-mode source ESI/APCI/ESCi
Auto tune: Automated optimization of ion optics and mass axis calibration in positive and negative ion modes using a proprietary tune solution
Solvent DE clustering: Optimized gas flow dynamic for efficient SEI desolations (supporting LC flow rate up to2ml/min)
Detector: Low noise off-axis, longe life photo multiplier detector
Vacuum system: Suitable rough pump for the optimum performance of the equipment with its oil. air cooled and shall have oil drip tray and quiet cover
MRM sensitivity Signal-to-Noise ratio (S/N) ESI positive measures > 30,000:1 Noise 1 pg on column injection with flow rate of 0.4ml/min in the range of 609 to 195m/z
Signal-to-Noise ratio (S/N) ESI negative measures> 10,000:1 Noise 1 pg on column injection with flow rate of 0.8ml/min in the range of 321 to 152 m/z
Mass range: 2 to 2050 m/z
Polarity switching: 20 ms
Mass resolution (auto tune): measures Full width at half maximum: 0.75 Da or better
Mass resolution (manual tune): FWHM : > 0.5 Da

Mass accuracy:
From 2 – 1,000 m/z - 0.01% max
Greater than 1,000  m/z - 0.02% max
Mass stability:  0.1 Da over 24 hr
Dynamic range: 4 x 10^6 or better
Scan modes: MS scan, MS/MS product ion scan, MRM, MS/MS neutral loss/gain scan and precursor ion scan, SIM
Maximum scan rate: Up to 10,000 Da/s
Minimum MRM dwell time: 1 ms
MRM transitions: 1000 per time segment > 32,000 ion transactions per MRM channel
Dynamic MRM transitions
Triggered MRM transitions:  up to 1000 MRM channels when operating in GLP or for library search and compound confirmation
Collision cell ion clearance: < 1 ms which enables for optimal MS/MS
Nitrogen Generator: With all its accessories (for at least 3 years)
Capacity:  Generates 32 L/min at 6.9 bar / 1.13 CFM at 100 psi
Operating Temperature: 5ºC to 35ºC
Relative Humidity: up to 80% Non-Condensing
Operating Altitude: Which is suitable for the Ethiopian (Addis Ababa) altitude range
Particles: < 0.01μm
Gas Outlets: 1x 1/4” BSP Female
Phthalates – None
Suspended Liquids: None
Noise Level: <54 dB(A) at 1m
Electrical Requirements: 220±10V, 50/60Hzs
Power Consumption: 1610 watts maximum
Dimensions (cm)
Weight (kg/ lbs) - 95 / 209
Annual Preventive maintenance kit shall be supplied with
Collision gas purity:  >99.99%, pure 1 cylinders gas with appropriate two stage pressure regulator should be offered
LC Tool kits and LC standards:  Caffeine standards kit for LC OQ/PV ESI+APCI LC demo sample for performance verification and training
Pump Kits: pump performance maintenance kit
Auto sampler preventive maintenance Kits
Detector maintenance Kits with chemical kit PM kits. Consists of: source component, ESI probe, Probe components and vacuum pump components
Nebulizer tools: Nebulizer adjustment fixture
Tool  for user serviceable elements like Screwdriver, wrench and others
Uninterrupted power supply (UPS): 5KVA or highest UPS suitable for the LC/MS/MS
Accessories: Low concentration tuning mix, performance check solutions: 100ml for each unit and 3pack
Needle and Needle Seat, Cartridge injection valve, Air filter side panel, Screw, Gold seal, Ferrules, Syringes, Tubing’s and capillaries, Label kit, Needle, Preventive maintenance
cleaning  kit, Solvent Bottle, O-range, Ion source cleaning kit, ESI and  API source service kit,
Air filter kit and all other components which enable an instrument run for at least one year to full capacity.

Columns:
C18:  4.6 x 150 mm, 3.5 μm - (Qyt  = 2pcs)
C18: 2.1mm x 50mm 1.7μm - (Qyt  = 2pcs)
C18: 4.6 x 100 mm, 2.7 μm - (Qyt  = 2pcs)
Guard Columns (Guard Cartridge): 2 pcs for each column indicated above

LC/MS/MS chemical supplies:
Positive and negative ion performance standard check and verification

MS/MS Supplies:
LC/MS PM Kit: rotaryperformance maintenance kit, with chemical kit consists of source component, ESI probe and vacuum pump component
Fore line vacuum pump oil - 3L